Time-restricted eating reveals a "younger" immune system and reshapes the intestinal microbiome in human.

ABSTRACT: Time-restricted eating (TRE) has been shown to extent lifespans in drosophila and mouse models by affecting metabolic and anti-inflammatory activities. However, the effect of TRE on the human immune system, especially on immunosenescence, intestinal microbiome, and metabolism remains unclear. We conducted a 30-day 16:8 TRE single-arm clinical trial with 49 participants. Participants consumed daily meals from 9 a.m. to 5 p.m., provided by a nutrition canteen with a balanced, calorie-appropriate nutrition, which is designed by clinical nutritionists (ChiCTR2200058137). We monitored weight changes and weight-related parameters and focused on changes in the frequency of CD4⁺ senescent T cells, immune repertoire from peripheral blood, as well as serum metabolites and gut microbiota.

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11616606 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature