Kinetics of elastic recovery in roll compaction.

ABSTRACT: Elastic recovery ( ER ) has been investigated and discussed extensively in the field of tableting. However, until now only limited data is available regarding ER in roll compaction. Therefore, a previously established in-line measurement technique was rolled out to further investigate the kinetics of ER in roll compaction and the effects of specific compaction force ( SCF ) and roll speed ( RS ). In-line laser triangulation measurements at different positions within a roll rotation as well as measurement over time after the process has been stopped were utilized. Pure microcrystalline cellulose ( MCC ) and two placebo powder blend formulations were analysed. Successful fit of the contained ER profiles emphasized that the ER on the roll surface is build out of two exponential kinetics. Star

SUBMITTER: Luck M 

PROVIDER: S-EPMC11616608 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature