<i>Chromobacterium</i> biopesticide overcomes insecticide resistance in malaria vector mosquitoes.

ABSTRACT: Vector mosquito control is an integral part of malaria control. The global emergence of insecticide resistance in malaria-transmitting Anophelines has become an impediment and has created an urgent need for novel mosquito control approaches. Here, we show that a biopesticide derived from the soil-dwelling bacterium Chromobacterium sp. Panama (Csp_P) kills insecticide-resistant Anopheles mosquitoes, regardless of their resistance mechanisms. In addition, sublethal dose of Csp_P acts as a synergist to now used chemical insecticides across multiple classes. Moreover, Csp_P reduces host-seeking behavior and malaria parasite infection in vector mosquitoes in ways that further decrease transmission. Mosquito glutathione S-transferases are essentia

SUBMITTER: Tikhe CV 

PROVIDER: S-EPMC11616681 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature