Nonheme iron catalyst mimics heme-dependent haloperoxidase for efficient bromination and oxidation.

ABSTRACT: The [Fe]/H₂O₂ oxidation system has found wide applications in chemistry and biology. Halogenation with this [Fe]/H₂O₂ oxidation protocol and halide (X^-) in the biological system is well established with the identification of heme-iron-dependent haloperoxidases. However, mimicking such halogenation process is rarely explored for practical use in organic synthesis. Here, we report the development of a nonheme iron catalyst that mimics the heme-iron-dependent haloperoxidases to catalyze the generation of HOBr from H₂O₂/Br^- with high efficiency. We discovered that a tridentate terpyridine (TPY) ligand designed for Fenton chemistry was optimal for FeBr₃ to form a stable nonheme iron catalyst [Fe(T

SUBMITTER: Zhao G 

PROVIDER: S-EPMC11616719 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature