The effect of intraoperative inosine infusion on transplant outcomes in deceased-donor kidney transplant recipients.

ABSTRACT:

Objectives

It is unknown when inosine was first employed as a renoprotective agent in the context of kidney transplantation procedures. However, there is no clinical evidence to support a protective role of inosine. The aim of this study was to investigate the effect of inosine on graft recovery.

Patients and methods

Data related to donors and recipients were retrieved from relevant records between 2015 and 2023. A total of 1138 kidney transplant cases were identified, including 1005 recipients who received a bolus of 1000 mg inosine and 133 recipients who did not receive inosine during transplantation surgery. The endpoints of the analysis included recipient recovery after transplantation as assessed by delayed graft function (DGF), peak estimated glomerular filtration rate

SUBMITTER: Luo Y 

PROVIDER: S-EPMC11616739 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature