Exploring the causal effect of complement and IgA nephropathy-a Mendelian randomization study.

ABSTRACT: IgA nephropathy, one of the most common primary glomerulonephritis worldwide, is still under investigation for its precise etiology. The widely accepted theory is the 'four-hit model' and subsequent complement and inflammatory responses. Recent studies have reported correlations between specific complement components and IgA nephropathy. However, the causal effects of genetically predicted complement components on IgA nephropathy require further elucidation. Our study aimed to determine the causal relationship between genetic predictors of complement and IgA nephropathy using the Mendelian randomization method. The primary analysis was initially conducted, examining heterogeneity and horizontal pleiotropy tests in each subgroup. Complement components with positive results were further anal

SUBMITTER: Xu H 

PROVIDER: S-EPMC11616755 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature