Comprehensive mapping of sensory and sympathetic innervation of the developing kidney.

ABSTRACT: The kidneys act as finely tuned sensors to maintain physiological homeostasis. Both sympathetic and sensory nerves modulate kidney function through precise neural control. However, how the kidneys are innervated during development to support function remains elusive. Using light-sheet and confocal microscopy, we generated anatomical maps of kidney innervation across development. Kidney innervation commences on embryonic day 13.5 (E13.5) as network growth aligns with arterial differentiation. Fibers are synapsin I⁺, highlighting ongoing axonogenesis and potential signaling crosstalk. By E17.5, axons associate with nephrons, and the network continues to expand postnatally. CGRP⁺, substance P⁺, TRPV1⁺, and PIEZO2⁺ sensory fibers and TH

SUBMITTER: N'Guetta PY 

PROVIDER: S-EPMC11616766 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature