Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Benzene is classified as carcinogenic to humans based on evidence that benzene causes acute myeloid leukemia. However, there is limited evidence that benzene causes lung cancer.

Objectives

We performed a systematic review, quality assessment, and meta-analysis of published cohort and case-control studies on the association between occupational benzene exposure and lung cancer risk.

Methods

We reviewed the relevant human epidemiological studies from PubMed and Embase databases to 19 August 2024. Data extraction included study characteristics, effect estimates, and exposure assessment details. Two investigators independently evaluated study quality using the Newcastle-Ottawa scale (NOS) framework and exposure assessment quality based on a priori criter

SUBMITTER: Wan W 

PROVIDER: S-EPMC11616769 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature