Global genomic epidemiology of bla _GES-5 carbapenemase-associated integrons.

ABSTRACT: Antimicrobial resistance (AMR) gene cassettes comprise an AMR gene flanked by short recombination sites (attI and attC or attC and attC). Integrons are genetic elements able to capture, excise and shuffle these cassettes, providing 'adaptation on demand', and can be found on both chromosomes and plasmids. Understanding the patterns of integron diversity may help to understand the epidemiology of AMR genes. As a case study, we examined the clinical resistance gene bla _GES-5, an integron-associated class A carbapenemase first reported in Greece in 2004 and since observed worldwide, which to our knowledge has not been the subject of a previous global analysis. Using a dataset comprising all de-duplicated NCBI contigs containing bla _GES

SUBMITTER: Matlock W 

PROVIDER: S-EPMC11616780 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature