Modulation of electrical activity of proteinoid microspheres with chondroitin sulfate clusters.

ABSTRACT: Proteinoids-thermal proteins-are produced by heating amino acids to their melting point and initiation of polymerisation to produce polymeric chains. Proteinoids swell in aqueous solution into hollow microspheres. The proteinoid microspheres produce endogenous burst of electrical potential spikes and change patterns of their electrical activity in response to illumination. These microspheres were proposed as proto-neurons in 1950s. To evaluate pathways of potential evolution of these proto-neurons and their applicability of chimera neuromorphic circuits we decided to hybridise them with hondroitin sulphate (CS) clusters, which form a part of the brain extracellular matrix. We found a novel synergistic interaction between CS clusters and proteinoids that dramatically affects patterns of ele

SUBMITTER: Mougkogiannis P 

PROVIDER: S-EPMC11616837 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature