Acute, Subchronic, and Genetic Toxicity Assessments of a Composition of <i>Citrus aurantifolia</i> Fruit Rind and <i>Theobroma cacao</i> Seed Extracts.

ABSTRACT: LN19183 is a standardized composition of Citrus aurantifolia (Christm) Swingle (CA) fruit rind and Theobroma cacao L. (TC) seed extracts that have recently been demonstrated to increase resting energy expenditure (REE) and reduce body fat in rats. CA and TC are important herbs in traditional medicine for various health benefits. The present study evaluates the comprehensive toxicity of LN19183 in acute, subchronic, and genetic toxicity studies following the guidelines of the Organization for Economic Co-operation and Development (OECD) for testing chemicals. The acute oral and dermal and 90-day subchronic oral toxicities were performed in rats, and acute dermal and eye irritations were performed in rabbits. In the subchronic toxicity study with a 28-day recovery period, male

SUBMITTER: Dodda S 

PROVIDER: S-EPMC11617045 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature