Functional T cells are capable of supernumerary cell division and longevity.

ABSTRACT: Differentiated somatic mammalian cells putatively exhibit species-specific division limits that impede cancer but may constrain lifespans^1-3. To provide immunity, transiently stimulated CD8⁺ T cells undergo unusually rapid bursts of numerous cell divisions, and then form quiescent long-lived memory cells that remain poised to reproliferate following subsequent immunological challenges. Here we addressed whether T cells are intrinsically constrained by chronological or cell-division limits. We activated mouse T cells in vivo using acute heterologous prime-boost-boost vaccinations⁴, transferred expanded cells to new mice, and then repeated this process iteratively. Over 10 years (greatly exceeding the mouse lifespan)⁵ and 51 successive immunization

SUBMITTER: Soerens AG 

PROVIDER: S-EPMC11617068 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature