Viscoelastic haemostatic assays to guide therapy in elective surgery: an updated systematic review and meta-analysis.

ABSTRACT:

Background

Patients undergoing major surgery frequently experience major uncontrolled bleeding. The aim of this systematic review and meta-analysis was to evaluate the clinical efficacy of using viscoelastic haemostatic assays to manage peri-operative bleeding in elective surgery.

Methods

We searched PubMed/MEDLINE and Embase databases for randomised controlled trials according to pre-determined criteria. The primary outcomes were blood product requirements; duration of stay in the operating theatre or ICU; and surgical reintervention rate.

Results

We included 20 randomised controlled trials. The overall risk of bias was low to moderate. Twelve studies used thromboelastography-based transfusion algorithms, while eight used thromboelastometry. Viscoelastic haemostatic

SUBMITTER: Dias JD 

PROVIDER: S-EPMC11617132 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature