Evaluation of the inhibitory mechanism of <i>Pennisetum glaucum</i> (pearl millet) bioactive compounds for rheumatoid arthritis: an <i>in vitro</i> and computational approach.

ABSTRACT:

Introduction

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial infiltration and pannus formation, and its rising incidence is significantly contributing to the global disability rate. Despite advances in biological drugs, no treatment has successfully cured or averted its progression. Consequently, natural drugs are being explored as alternative therapeutic strategies.

Objective

This study aims to evaluate the therapeutic potential of Pennisetum glaucum (pearl millet) and to identify its bioactive compounds to assess their effectiveness against RA targets.

Methods

The therapeutic potential of P. glaucum extracts was evaluated by antioxidant and anti-inflammatory assays. Gas chromatography-mass spectrometry (GC-MS) was ut

SUBMITTER: Sharif M 

PROVIDER: S-EPMC11617165 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature