Allopregnanolone and mood in the peripartum: a longitudinal assessment in healthy women.

ABSTRACT:

Background

Allopregnanolone (ALLO), a neuroactive steroid hormone derived from progesterone, can modulate mood via the GABA-A receptor. Peripartum mood can be influenced by psychosocial factors, previous mental illness, and hormonal changes. Studies suggest a U-shaped effect of ALLO on mood, with some women being more sensitive to hormonal changes than others. However, research in the peripartum is inconclusive.

Methods

This study explored the link between salivary ALLO and mood during the peripartum. Over 12 weeks, N = 61 women completed the Edinburgh Postnatal Depression Scale and the State Anxiety subscale from the State-Trait Anxiety Inventory and provided saliva samples. Salivary ALLO was analyzed using an enzyme-linked immunosorbent assay, validated for saliva samples.

SUBMITTER: Grotsch MK 

PROVIDER: S-EPMC11617183 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature