External validation of the Leiden Thrombosis Recurrence Risk Prediction models (L-TRRiP) for the prediction of recurrence after a first venous thrombosis in the Heart and Vascular Health study.

ABSTRACT:

Background

Long-term outcome after a first venous thromboembolism (VTE) might be optimized by tailoring anticoagulant treatment duration on individual risks of recurrence and major bleeding. The L-TRRiP models (A-D) were previously developed in data from the Dutch Multiple Environment and Genetic Assessment of Risk Factors for Venous thrombosis study to predict VTE recurrence.

Objectives

We aimed to externally validate models C and D using data from the United States Heart and Vascular Health (HVH) study.

Methods

Data from participants with a first VTE who discontinued initial anticoagulant therapy were used to determine model performance. Missing data were imputed, and results were pooled according to Rubin's rules. To determine discrimination, Harrell's C-statistic

SUBMITTER: Burggraaf-van Delft JLI 

PROVIDER: S-EPMC11617231 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature