Cardiac risk and myocardial fibrosis assessment with cardiac magnetic resonance in patients with myotonic dystrophy.

ABSTRACT:

Introduction

Non-invasive evaluation of myocardial tissue is a major goal of cardiac imaging. This is the case of myocardial fibrosis which is crucial in many myocardial diseases. Cardiac extracellular volume (ECV) was shown to indicate myocardial fibrosis and early cardiac involvement. With this study, our objective is to evaluate ECV measured with cardiac magnetic resonance (CMR) in patients with myotonic dystrophy type 1 (DM1) and 2 (DM2) as potential imaging biomarkers of subclinical cardiac pathology, and its relationship with demographic and clinical parameters, ECG-derived measures of cardiac conduction, and neuromuscular performance status.

Materials and methods

We retrospectively analyzed 18 DM1 patients and 4 DM2 patients without apparent cardiac disease who had CM

SUBMITTER: Abati E 

PROVIDER: S-EPMC11617365 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature