Extended range proteomic analysis of blood plasma from schizophrenia patients.

ABSTRACT:

Introduction

The high prevalence of schizophrenia worldwide makes it necessary to proceed from subjective assessment of patient's clinical symptoms in diagnosis making to searching for circulating blood biomarkers. On the one hand, searching for molecular markers and targets for therapeutics will make it possible to refine and detail the molecular mechanisms of pathology development, while on the other hand, it will offer new opportunities for elaborating novel approaches to disease diagnosis and enhance efficacy and timeliness of drug therapy.

Methods

In this study, we performed an extended-range proteomic analysis of plasma samples collected from 48 study subjects with confirmed diagnosis of schizophrenia and 50 healthy volunteers. The high-resolution tandem mass spectra r

SUBMITTER: Petrovskiy DV 

PROVIDER: S-EPMC11617367 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature