Associations of plasma SMOC1 and soluble IL6RA levels with the progression from mild cognitive impairment to dementia.

ABSTRACT: Despite the central role attributed to neuroinflammation in the etiology and pathobiology of Alzheimer's disease (AD), the direct link between levels of inflammatory mediators in blood and cerebrospinal fluid (CSF) compartments, as well as their potential implications for AD diagnosis and progression, remains inconclusive. Moreover, there is debate on whether inflammation has a protective or detrimental effect on disease onset and progression. Indeed, distinct immunological mechanisms may govern protective and damaging effects at early and late stages, respectively. This study aims to (i) identify inflammatory mediators demonstrating robust correlations between peripheral and central nervous system (CNS) compartments by means of plasma and CSF analysis, respectively, and (ii) assess their

SUBMITTER: Morato X 

PROVIDER: S-EPMC11617377 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature