Midlife heart rate variability and cognitive decline: A large longitudinal cohort study.

ABSTRACT:

Background

Autonomic dysfunction is common in dementia, yet its contribution to neurocognitive changes remains unknown. We investigated whether midlife cardiac vagal modulation, indexed by heart rate variability, associates with subsequent cognitive decline in adults without prior coronary heart disease or stroke.

Methods

The sample comprised 2702 (1924 men) individuals initially aged 44-69 years from the UK Whitehall II cohort. Data from the fifth (1997-1999), seventh (2002-2004) and ninth (2007-2009) phases were analysed. Global cognitive function was ascertained from tests assessing memory, reasoning, vocabulary, and fluency. We used 12-lead-ECG-based heart rate variability measures, that primarily reflect vagal modulation (i.e. RMSSD and HF-HRV). Linear mixed-effects mod

SUBMITTER: Jandackova VK 

PROVIDER: S-EPMC11617396 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature