PTX3 is expressed in terminal lymphatics and shapes their organization and function.

ABSTRACT:

Introduction

The lymphatic system is a multifaceted regulator of tissue homeostasis and an integral part of immune responses. Previous studies had shown that subsets of lymphatic endothelial cells (LEC) express PTX3, an essential component of humoral innate immunity and tissue homeostasis.

Methods

In the present study using whole-mount imaging and image-based morphometric quantifications, Ptx3-targeted mice and in vivo functional analysis, we investigated the involvement of PTX3 in shaping and function of the lymphatic vasculature.

Results

We found that PTX3 is localized in the extracellular matrix (ECM) surrounding human and murine lymphatic vessels (LV). In murine tissues, PTX3 was localized in the ECM close to LV terminals and sprouting. Ptx

SUBMITTER: Doni A 

PROVIDER: S-EPMC11617523 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature