Mediation effects of metabolites and sex hormones on the relationship between body mass index and breast cancer: Mendelian randomization analysis and mediation analysis.

ABSTRACT:

Background

Observational investigations have indicated a notable correlation between body mass index (BMI) and breast cancer (BC). Nevertheless, the precise biological pathways driving this correlation remain ambiguous. Consequently, we utilized Mendelian randomization (MR) techniques to explore the causative link between BMI and genetic predisposition to BC, as well as the potential intermediary influences.

Methods

Utilizing extensive cohorts sourced from publicly accessible genome-wide association studies (GWAS) datasets of European populations, we conducted Mendelian randomization (MR) analysis. The primary method employed was the Inverse Variance Weighted (IVW) model. We evaluated both heterogeneity and horizontal pleiotropy. Our MR analysis unveiled several metabolites

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11617525 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature