Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study.

ABSTRACT:

Background

Acute Respiratory Distress Syndrome (ARDS) is a severe lung condition posing significant health risks. Observational studies have indicated a potential linkage between ARDS and various interleukins, such as Interleukin-8, -2, -6, and -1β. However, the causal relationships between specific interleukins, their receptors, and ARDS remain unclear.

Methods

This study employed bidirectional Mendelian Randomization (MR) to investigate the causal associations between 197 different interleukins, interleukin receptors, and ARDS. GWAS summary data for interleukins and their receptors were sourced from publicly available studies, while ARDS data were derived from the FinnGen database. Wald Ratio and Inverse Variance Weighted (IVW) methods were primarily utilized in the MR ana

SUBMITTER: Ma JW 

PROVIDER: S-EPMC11617530 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature