The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress.

ABSTRACT:

Background

Liver cancer presents a significant challenge to global health and is currently ranked as the sixth most common form of cancer worldwide. Recent research indicates that phosphodiesterases play a role in various physiological and pathological processes, with a specific focus on their impact on cancer advancement. There is a scarcity of studies investigating the function and mechanisms of phosphodiesterases in the development and progression of hepatocellular carcinoma (HCC).

Methods

Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) and Western blotting were employed to analyze the expression of PDE7B in hepatocellular carcinoma tissues and cells. The biological role of PDE7B in HCC was investigated by both overexpressing and knocking down PDE7

SUBMITTER: Luo Y 

PROVIDER: S-EPMC11617559 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature