A scaling relationship between thermodynamic and hydrodynamic interactions in protein solutions.

ABSTRACT: Weak protein interactions are associated with a broad array of biological functions and are often implicated in molecular dysfunction accompanying human disease. In addition, these interactions are a critical determinant in the effective manufacturing, stability, and administration of biotherapeutic proteins. Despite their prominence, much remains unknown about how molecular attributes influence the hydrodynamic and thermodynamic contributions to the overall interaction mechanism. To systematically probe these contributions, we have evaluated self-interaction in a diverse set of proteins that demonstrate a broad range of behaviors from attractive to repulsive. Analysis of the composite trending in the data provides a convenient interconversion among interaction parameters measured from the

SUBMITTER: Kingsbury JS 

PROVIDER: S-EPMC11617628 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature