'GGFGGQ' repeats in Hfq of Acinetobacter baumannii are essential for nutrient utilization and virulence.

ABSTRACT: The nosocomial pathogen Acinetobacter baumannii is known for causing lung and soft tissue infections in immunocompromised hosts. Its ability to adapt to various environments through post-transcriptional gene regulation is key to its success. Central to this regulation is the RNA chaperone Hfq, which facilitates interactions between mRNA targets and their small RNA partners through a Sm-core domain. Notably, the A. baumannii Hfq protein has a uniquely long C-terminal domain with "GGFGGQ" amino acid repeats and an acidic amino acid-rich C-terminal tip (C-tip). Previous research has shown the importance of the intact C-terminal domain for Hfq's functionality. Given the significance of the C-tip in Escherichia coli Hfq, we examined the pathophysiological roles of the redundant 'GGFGGQ' repeats

SUBMITTER: Sett A 

PROVIDER: S-EPMC11617691 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature