Dissecting the pathogenic effects of smoking in blood DNA methylation on allergic diseases.

ABSTRACT:

Background

Allergic diseases, such as asthma and allergic rhinitis, present significant health challenges globally. Elucidating the genetic and epigenetic foundations is crucial for developing effective interventions.

Methods

We performed two-sample Mendelian Randomization (MR) analyses to investigate the associations between smoking behaviors and various allergic diseases, leveraging data from the FinnGen database. Additionally, we examined the relationships of DNA methylation (CpG sites) with allergic diseases, employing mQTLs as epigenetic proxies. Furthermore, we conducted reverse MR analyses on CpG sites that exhibited cross-allergic disease effects.

Results

In our genomic MR analysis, smoking behaviors such as smoking initiation and the number of cigarettes smok

SUBMITTER: Tu J 

PROVIDER: S-EPMC11617736 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature