No causal relationship between ankylosing spondylitis and Parkinson's disease: Insights from Mendelian randomization studies.

ABSTRACT:

Background

Retrospective cohort and cross-sectional studies have indicated an association between ankylosing spondylitis (AS) and Parkinson's disease (PD). However, owing the multitude of limitations, a consistent conclusion has not been determined. Furthermore, whether a causal relationship exists between these two diseases remains unclear.

Methods

We conducted a two-way Mendelian randomization (MR) analysis using genome-wide association study data. For patients with PD, we utilised data from the ieu-b-7 database, whereas for patients with AS, we employed the three databases with the largest sample sizes for a combined analysis. These databases included ebi-a-GCST005529, finn-b-M13 ANKYLOSPON, and finn-b-M13 ANKYLOSPON STRICT. Our primary method of analysis was inverse vari

SUBMITTER: Chen J 

PROVIDER: S-EPMC11617765 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature