Synthesis, characterization, molecular docking and pharmacological evaluation of isoxazole derivatives as potent anti-inflammatory agents.

ABSTRACT:

Background

The present study is aimed to investigate the anti-inflammatory activities of thirteen substituted-isoxazole derivatives (5a-5m). Isoxazole is a key pharmacophore in medicinal chemistry, known for its broad range of pharmacological activities.This study explores the synthesis and anti-inflammatory potential of thirteen substituted-isoxazole derivatives (5a-5m), with 5c, 5d, 5e, and 5g being novel compounds.

Objectives

The primary objectives were to synthesize some novel substituted isoxazole derivatives, evaluate their interaction with cyclooxygenase (COX-1/2) enzymes through computational methods, and assess their anti-inflammatory effectiveness in laboratory animals.

Methods

Substituted chalcones (0.01 mol) (2a-2m), sodium ethoxide (0.01 mol

SUBMITTER: Sonu 

PROVIDER: S-EPMC11617876 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature