Screening for depression in the general population through lipid biomarkers.

ABSTRACT:

Background

Anxiety and depression significantly contribute to the overall burden of mental disorders, with depression being one of the leading causes of disability. Despite this, no biochemical test has been implemented for the diagnosis of these mental disorders, while recent studies have highlighted lipids as potential biomarkers.

Methods

Using a streamlined high-throughput lipidome analysis method, direct-infusion mass spectrometry, we evaluated blood plasma lipid levels in 604 individuals from a general urban population and analysed their association with self-reported anxiety and depression symptoms. We also assessed lipidome profiles in 32 patients with clinical depression, matched to 21 healthy controls.

Findings

We found a significant correlation between lipid

SUBMITTER: Tkachev A 

PROVIDER: S-EPMC11617895 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature