Development and evaluation of an antigen targeting lateral flow test for Crimean-Congo Haemorrhagic Fever.

ABSTRACT:

Background

Crimean-Congo Haemorrhagic Fever (CCHF) is a viral haemorrhagic fever with a case fatality rate of 5-25% that has been prioritised for research and development by the World Health Organisation. There are no CCHF rapid diagnostic tests (RDTs) commercially available. We describe the development and evaluation of an antigen-targeting lateral flow immunoassay RDT for CCHF.

Methods

Prospective clinical samples were collected and tested between July and October 2023 in Türkiye. Retrospective stored samples were obtained from the Central Public Health Laboratory, Baghdad, Iraq. The sensitivity and specificity of the CCHF RDT was compared to reverse transcription quantitative polymerase chain reaction assays.

Findings

On prospective clinical samples in Türkiye, the

SUBMITTER: Thompson CR 

PROVIDER: S-EPMC11617902 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature