Impact of maternal health and stress on steroid hormone profiles in human milk: Implications for infant development.

ABSTRACT: Steroid hormones are biologically active factors in human milk (HM) that influence the physical and mental development of infants. Critically, maternal psychosocial stress has been associated with changes in HM steroid composition. This work aimed to characterize the steroid hormone profile of HM and pasteurized donor human milk (DHM) and assess the interplay between maternal physical and psychosocial status, the HM steroid profile, and infant outcomes. A targeted ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed to quantify sixteen steroid hormones in HM samples. HM samples from mothers of term infants (N = 42) and preterm infants (N = 35) were collected at (i) recovery of birth weight or achievement of complete enteral nutrition, respectiv

SUBMITTER: Ten-Domenech I 

PROVIDER: S-EPMC11617944 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature