Untargeted lipidomics reveals novel HDL metabotypes and lipid-clinical correlates.

ABSTRACT: Plasma high-density lipoprotein (HDL), originally studied for its role in lipid transport, is now appreciated to have wide-ranging biological functions that become defective during disease. While >200 lipids have collectively been detected in HDL, published HDL lipidomic analyses in different diseases have commonly been targeted to prespecified subsets of lipids. Here, we report the results of untargeted lipidomic analysis of HDL isolated from 101 subjects referred for computed tomographic coronary imaging for whom multiple additional clinical and lipoprotein metadata were measured. Unsupervised clustering of the total HDL lipidome revealed that the subjects fell into one of two discrete groups, herein referred to as HDL "metabotypes." Patients in metabotype 1 were likelier to be female an

SUBMITTER: Karmaus PWF 

PROVIDER: S-EPMC11617998 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature