Bifunctional Hexadentate Pyclen-Based Chelating Agent for Mild Radiofluorination in Aqueous Solution at Room Temperature with a Ga-¹⁸F Ternary Complex.

ABSTRACT: Positron Emission Tomography (PET) is used in oncology for tumor diagnosis, commonly relying on fluorine-18 (¹⁸F) emission detection. The conventional method of ¹⁸F incorporation on to probes by covalent bonding is harsh for sensitive biomolecules, which are nonetheless compounds of choice for the development of targeted probes. This study explores gallium-¹⁸F (Ga¹⁸F) coordination, a milder alternative method occurring in aqueous media at the final stage of radiosyntheses. Pyclen-based chelating agents were proposed to capture (GaF) species at room temperature and pH≥5 making the radiofluorination process compatible with heat- and acid-sensitive biomolecules. Highly promising results were obtained with the PC2A-based chelating agent LH₂

SUBMITTER: Dioury F 

PROVIDER: S-EPMC11618045 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature