Adult skull bone marrow is an expanding and resilient haematopoietic reservoir.

ABSTRACT: The bone marrow microenvironment is a critical regulator of haematopoietic stem cell self-renewal and fate¹. Although it is appreciated that ageing, chronic inflammation and other insults compromise bone marrow function and thereby negatively affect haematopoiesis², it is not known whether different bone compartments exhibit distinct microenvironmental properties and functional resilience. Here we use imaging, pharmacological approaches and mouse genetics to uncover specialized properties of bone marrow in adult and ageing skull. Specifically, we show that the skull bone marrow undergoes lifelong expansion involving vascular growth, which results in an increasing contribution to total haematopoietic output. Furthermore, skull is largely protected against major hallmar

SUBMITTER: Koh BI 

PROVIDER: S-EPMC11618084 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature