Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis.

ABSTRACT: The circadian rhythm of the immune system helps to protect against pathogens^1-3; however, the role of circadian rhythms in immune homeostasis is less well understood. Innate T cells are tissue-resident lymphocytes with key roles in tissue homeostasis^4-7. Here we use single-cell RNA sequencing, a molecular-clock reporter and genetic manipulations to show that innate IL-17-producing T cells-including γδ T cells, invariant natural killer T cells and mucosal-associated invariant T cells-are enriched for molecular-clock genes compared with their IFNγ-producing counterparts. We reveal that IL-17-producing γδ (γδ17) T cells, in particular, rely on the molecular clock to maintain adipose tissue homeostasis, and exhibit a robust circadian rhythm for RORγt and IL-17A across adi

SUBMITTER: Douglas A 

PROVIDER: S-EPMC11618085 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature