Coupling of unactivated alkyl electrophiles using frustrated ion pairs.

ABSTRACT: Cross-electrophile coupling reactions have evolved into a major strategy for rapidly assembling important organic molecules¹. Two readily accessible electrophiles are coupled to form new C-C bonds, providing a key advantage over traditional cross-coupling strategies that require the preformation of reactive organometallic species. Yet, the formation of C(sp³)-C(sp³) bonds that form the core of nearly all organic compounds remains highly challenging with current approaches, calling for the design of innovative new strategies. Here we report a distinct, transition-metal-free platform to form such bonds without the need for activating or stabilizing groups on the coupling partners. The reaction is enabled by an unusual single-electron transfer in a frustrated

SUBMITTER: Roediger S 

PROVIDER: S-EPMC11618088 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature