Plasticity and environment-specific relationships between gene expression and fitness in Saccharomyces cerevisiae.

ABSTRACT: The environment influences how an organism's genotype determines its phenotype and how this phenotype affects its fitness. Here, to better understand this dual role of environment in the production and selection of phenotypic variation, we determined genotype-phenotype-fitness relationships for mutant strains of Saccharomyces cerevisiae in four environments. Specifically, we measured how promoter mutations of the metabolic gene TDH3 modified expression level and affected growth for four different carbon sources. In each environment, we observed a clear relationship between TDH3 expression level and fitness, but this relationship differed among environments. Mutations with similar effects on expression in different environments often had different effects on fitness and vice versa. Such env

SUBMITTER: Siddiq MA 

PROVIDER: S-EPMC11618099 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature