Electrical graft assessment of machine-perfused hearts donated after circulatory death.

ABSTRACT:

Background

Normothermic ex situ heart perfusion (ESHP) has increased the donor pool with hearts donated after circulatory death (DCD), but functional assessment during ESHP using lactate trends is suboptimal. This study presents the clinical use of high-resolution cardiac mapping to assess electrical function of human DCD hearts on ESHP, where low-voltage-areas might be indicative of myocardial injury.

Methods

Hearts were procured following circulatory arrest of the donor and restarted on normothermic ESHP. DCD hearts were transported to the recipient hospital and lactate concentrations were regularly measured in the perfusate. High-resolution epicardial mapping of the left (LV) and right ventricle (RV) was performed with a 192-electrode array during normothermic ESHP prior

SUBMITTER: Amesz JH 

PROVIDER: S-EPMC11618120 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature