Effectiveness and safety of insulin glargine 300 U/mL in insulin-naive individuals according to diabetes duration: Results from the REALI European pooled data analysis.

ABSTRACT:

Aim

To evaluate the effectiveness and safety of insulin glargine 300 U/mL (Gla-300) initiation according to diabetes duration (DD).

Materials and methods

We analysed patient-level data from 2381 insulin-naïve individuals with type 2 diabetes (T2D), of whom 2349 (98.7%) were treated with Gla-300 for 24 weeks. Of the 2381 participants, 1048 (44.0%) had a DD of less than 8 years and 1333 (56.0%) had a DD of 8 years or longer. We further analysed the subgroups of participants having a DD of less than 4 years (N = 450), 4-8 years (N = 598), 8-12 years (N = 627) and 12 years or longer (N = 706).

Results

Mean ± standard deviation age was 60.2 ± 9.0 years in participants with a DD less than 8 years and 64.2 ± 8.8 years in those with a DD of 8 years or longer. At 24 weeks of G

SUBMITTER: Gourdy P 

PROVIDER: S-EPMC11618222 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature