Modeling Fibrin Accumulation on Flow-Diverting Devices for Intracranial Aneurysms.

ABSTRACT: The mechanisms leading to aneurysm occlusion after treatment with flow-diverting devices are not fully understood. Flow modification induces thrombus formation within the aneurysm cavity, but fibrin can simultaneously accumulate and cover the device scaffold, leading to further flow modification. However, the interplay and relative importance of these processes are not clearly understood. A computational model of fibrin accumulation and flow modification after flow diversion treatment of cerebral aneurysms has been developed under the guidance of in vitro experiments and observations. The model is based on the loose coupling of flow and transport-reaction equations that are solved separately by independent codes. Interaction or reactive terms account for thrombin production from prothrombi

SUBMITTER: Cebral JR 

PROVIDER: S-EPMC11618230 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature