Trajectory, interactions, and predictors of higher symptom burden during induction therapy for multiple myeloma.

ABSTRACT:

Background

Patients with multiple myeloma (MM) experience disabling symptoms that are difficult to manage and may persist after induction therapy. Monitoring disease-related and induction therapy-induced symptoms and identifying patients at greater risk for high symptom burden are unmet clinical needs. The objective of this study was to examine the trajectories of symptom severity over time and identify predictors of high symptom burden during MM induction therapy.

Methodology

Eligible patients with MM rated their symptoms by completing the MD Anderson Symptom Inventory MM module repeatedly during 16 weeks of induction therapy. Group-based trajectory modeling identified patient groups with persistently high-severity (versus low-severity) symptom trajectories over time. Quali

SUBMITTER: Kamal M 

PROVIDER: S-EPMC11618278 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature