Low-calorie, high-protein diets, regardless of protein source, improve glucose metabolism and cardiometabolic profiles in subjects with prediabetes or type 2 diabetes and overweight or obesity.

ABSTRACT:

Aim

The aim was to study the effect of two low-calorie, high-protein (HP) diets, with most of the protein coming from animal or plant sources, on glycaemic and other cardiometabolic outcomes in subjects with overweight or obesity and glucose metabolism disorders.

Materials and methods

A total of 117 participants aged >18 years with body mass index over 27.5 kg/m² and prediabetes or type 2 diabetes mellitus (T2DM) were randomized to one of two HP low-calorie diets (35% of total calories from protein), in which 75% of the protein was from either plant-based sources (HPP) or animal sources (HPA). For both diets, 30% and 35% of the total calories were from fat and carbohydrates, respectively. The dietary intervention lasted 6 months.

Results

Both diets improved

SUBMITTER: Rodrigo-Carbo C 

PROVIDER: S-EPMC11618321 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature