Photocatalytic therapy via photoinduced redox imbalance in biological system.

ABSTRACT: Redox balance is essential for sustaining normal physiological metabolic activities of life. In this study, we present a photocatalytic system to perturb the balance of NADH/NAD⁺ in oxygen-free conditions, achieving photocatalytic therapy to cure anaerobic bacterial infected periodontitis. Under light irradiation, the catalyst TBSMSPy⁺ can bind bacterial DNA and initiate the generation of radical species through a multi-step electron transfer process. It catalyzes the conversion from NADH to NAD⁺ (the turnover frequency up to 60.7 min^-1), inhibits ATP synthesis, disrupts the energy supply required for DNA replication, and successfully accomplishes photocatalytic sterilization in an oxygen-free environment. The catalyst participates in the redox r

SUBMITTER: Zhou K 

PROVIDER: S-EPMC11618361 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature