Kinetics and Optimization Studies of Controlled 5-Fluorouracil Release from Graphene Oxide Incorporated Vegetable Oil-Based Polyurethane Composite Film.

ABSTRACT: The current study focuses on investigating the potential of produced graphene oxide (GO)/oil-based polyurethane composite films as a drug carrier for 5-fluorouracil (5-FU). Polyurethane was synthesized starting from blends of castor oil and sunflower oil-based glyceride, followed by GO and 5-FU anticancer drug bearing film production by solution casting. GO/PU composite film samples were characterized by FTIR, TGA and SEM analysis, confirming the PU production and distribution of 5-FU drug at a homogeneous level in GO/PU films. Experimental design studies were carried out to provide insight into the influence of GO incorporation, the amount of loaded drug, and the release medium pH value on 5-FU release behavior. The amount of 5-FU delivered from GO/PU composites displayed a tendency to in

SUBMITTER: Kahraman E 

PROVIDER: S-EPMC11618446 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature