Spatiotemporal modeling quantifies cellular contributions to uptake of Aspergillus fumigatus in the human lung.

ABSTRACT: The human lung is confronted daily with thousands of microbial invaders reaching the lower respiratory tract. An efficient response by the resident type 1 and type 2 alveolar epithelial cells (AECs) and alveolar macrophages (AMs) cells during the early hours of innate immunity is a prerequisite to maintain a non-inflammatory state, but foremost to rapidly remove harmful substances. One such human-pathogenic invader is the opportunistic fungus Aspergillus fumigatus. If the spherical conidia are not cleared in time, they swell reaching approximately twice of their initial size and germinate to develop hyphae around six hours post-infection. This process of morphological change is crucial as it enables the pathogen to invade the alveolar epithelium and to reach the bloodstream, but also makes

SUBMITTER: Saffer C 

PROVIDER: S-EPMC11618450 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature