Risk of Intracranial Hemorrhage Associated With Direct Oral Anticoagulation vs Antiplatelet Therapy: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

For patients with atrial fibrillation, clinicians often prescribe antiplatelet therapy rather than oral anticoagulation, which may be related to a concern that direct oral anticoagulants (DOACs) are associated with a higher risk of intracranial bleeding, despite being less effective for stroke prevention.

Objective

To determine whether DOAC therapy, compared with single-agent antiplatelet therapy, was associated with an increased risk of intracranial and major hemorrhage.

Data sources

A systematic search of PubMed and Embase databases from inception to February 7, 2024, was performed.

Study selection

Randomized clinical trials that compared DOAC therapy with single-agent antiplatelet therapies were included. Trials with active follow-up of less than

SUBMITTER: Coyle M 

PROVIDER: S-EPMC11618459 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature