Microglial activation without peripheral immune cell infiltration characterises mouse and human cerebral small vessel disease.

ABSTRACT:

Aims

Cerebral small vessel diseases (SVDs) involve diverse pathologies of the brain's small blood vessels, leading to cognitive deficits. Cerebral magnetic resonance imaging (MRI) reveals white matter hyperintensities (WMHs), lacunes, microbleeds and enlarged perivascular spaces in SVD patients. Although correlations of MRI and histopathology help to understand the pathogenesis of SVD, they do not explain disease progression. Mouse models, both genetic and sporadic, are valuable for studying SVD, but their resemblance to clinical SVD is unclear. The study examined similarities and differences between mouse models of SVDs and human nonamyloid SVD specimens.

Methods

We analysed four mouse models of SVD (hypertensive BPH mice, Col4a1 mutants, Notch3 mutants and Htra1^-/-

SUBMITTER: Deshpande T 

PROVIDER: S-EPMC11618487 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature