Microglia induce an interferon-stimulated gene expression profile in glioblastoma and increase glioblastoma resistance to temozolomide.

ABSTRACT:

Aims

Glioblastoma is the most malignant primary brain tumour. Even with standard treatment comprising surgery followed by radiation and concomitant temozolomide (TMZ) chemotherapy, glioblastoma remains incurable. Almost all patients with glioblastoma relapse owing to various intrinsic and extrinsic resistance mechanisms of the tumour cells. Glioblastomas are densely infiltrated with tumour-associated microglia and macrophages (TAMs). These immune cells affect the tumour cells in experimental studies and are associated with poor patient survival in clinical studies. The aim of the study was to investigate the impact of microglia on glioblastoma chemo-resistance.

Methods

We co-cultured patient-derived glioblastoma spheroids with microglia at different TMZ concentrations and an

SUBMITTER: Sorensen MD 

PROVIDER: S-EPMC11618491 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature