Phenotypic and epigenetic heterogeneity in FGFR2-fused glial and glioneuronal tumours.

ABSTRACT:

Aims

FGFR-fused central nervous system (CNS) tumours are rare and are usually within the glioneuronal and neuronal tumours or the paediatric-type diffuse low-grade glioma spectrum. Among this spectrum, FGFR2 fusion has been documented in tumours classified by DNA-methylation profiling as polymorphous low-grade neuroepithelial tumours of the young (PLNTY), a recently described tumour type. However, FGFR2 fusions have also been reported in glioneuronal tumours, highlighting the overlapping diagnostic criteria and challenges.

Methods

We investigated the FGFR2 fusion landscape in a French national series of tumours sent to the RENOCLIP-LOC network. We comprehensively analysed histology, radiology and molecular data including DNA-methylation profiling for 16 FGFR2-fused glioneuro

SUBMITTER: Metais A 

PROVIDER: S-EPMC11618513 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature